Kaelin horst biography of christopher

Christopher Kaelin
BornChristopher Kaelin
(1973-05-26)May 26, 1973[1]
San Mateo California, U.S.
🏡 ResidenceRedwood Get, California
🏳️ NationalityAmerican
💼 Occupation
Known for*Discovery show the spotting gene in felines
  • Discovery of gene for install and skin color
  • Research on distinction gene that controls weight regulation
👩 Spouse(s)Jen Chu Kaelin
👶 ChildrenOne son

Christopher Bryan Kaelin is a geneticist and pigmentation scientist at University University.

He is also justness senior scientist in Gregory Barsh's lab, in residence in honesty Tang Lab. Kaelin has solitary several significant genes: one reliable for spotting in felines; skirt which produces color in dog; another responsible for skin skin texture. His genetic research is further studied for its impact finding weight regulation.

Career and research

As the senior scientist for Greg Barsh, (Greg Barsh is efficient geneticist and pigmentation scientist soothe Stanford University and the Navigator Alpha Institute of Biotechnology get a move on Huntsville, Ala.)[2]

Kaelin has studied appearance and pattern variations in pour and cats.

He was tangled in the discovery of out gene that makes a catalyst called a defensin. Those Defensins may be the key fall upon understanding color in dogs.[3]

Kaelin additionally studied the production of scared versus black pigment in come down, which is controlled by tierce genes: Mc1r, Agouti, and CBD103. Kaelin proved that the Topping β-Defensin Mutation Causes Black Cover Color in Domestic Dogs [4] Transgenic mice grew black wealth after being inserted with loftiness gene.[5]

Researching the marble and speckled genes in felines

Kaelin's research has been used to identify dignity spotted gene in domestic Bengal cats.

Bengal breeders were kind in finding out which rearing cats carried the gene in line for marble bengals and which cultivation cats are pure for espial or rosetting. "Domestic cats have to one`s name four distinct and heritable dirty patterns – ticked, mackerel, splotched, and spotted – these trim collectively referred to as queen markings."[6] Kaelin studied the gain and pattern variations of unbroken cats in Northern California, paramount was able to identify nobility gene responsible for the stone pattern in Bengal cats.[7][8] Let go identified the gene responsible form tabby pattern variation in help cats as Transmembrane Aminopeptidase Contradictory (Taqpep), which encodes a membrane-bound Metalloproteinase.

Analyzing 31 other carnivore species, he identified Taqpep makeover the cause of the hardly any king cheetah phenotype, in which spots coalesce into blotches stomach stripes.[9][10][11][12]

Kaelin claims that basic constitutional research—identifying genes and their connection to color and pattern—may be endowed with a serendipitous benefit.

I.e., udication causes and leads to cures for disease.

References

  1. ↑Kaelin, Christopher. "Christopher Kaelin". Facebook. Facebook. Retrieved 17 June 2019.
  2. ↑"Scientists unlock the obscurity of cats' stripes SEPTEMBER 20, 2012". CBS news. The Relative Press.

    20 September 2012. Retrieved 8 May 2019.

  3. ↑Stephens, Tim. "Discovery of gene for black cagoule color in dogs has extensive implications". news.ucsc. REGENTS OF Nobleness UNIVERSITY OF CALIFORNIA. Retrieved 24 April 2019.
  4. ↑"A β-Defensin Mutation Causes Black Coat Color in Drudge Dogs".

    American Association for honourableness Advancement of Science. Retrieved 24 April 2019.

  5. ↑SPECTOR, ROSANNE. "Scientists snuff out gene that makes pursue fur black". stanford. Stanford Establishing. Retrieved 24 April 2019.
  6. ↑Barsh, Greg; Kaelin, Christopher.

    "Tabby pattern inheritance – a whole new produce of cat". onlinelibrary. John Wiley & Sons, Inc. Retrieved 24 April 2019.

  7. ↑"One way to pelt a cat – same genes behind blotches of tabbies have a word with king cheetahs". National Geographic Partners. nationalgeographic. Retrieved 1 May 2019.
  8. ↑Conger, Krista.

    "How the cheetah got its stripes: A genetic inform by Stanford researchers". Stanford. University University. Retrieved 10 March 2019.

  9. ↑"Specifying and Sustaining Pigmentation Patterns withdraw Domestic and Wild Cats". Science (6101): 1536–1541. 21 Sep 2012. doi:10.1126/science.1220893.
  10. ↑Norton, Elizabeth (September 20, 2012).

    "How the Tabby Got Treason Blotches". Science. Retrieved April 26, 2019.

  11. ↑"One Gene Lays The Draw for A Cheetah's Spots Weather A Tabby Cat's Stripes". Popular Science. Retrieved 1 May 2019.
  12. ↑"How the Tabby Got Its Blotches". sciencemag. American Association for prestige Advancement of Science.

    Retrieved 1 May 2019.

External links


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